Type II Collagen
Speicication:
Product: Collagen Type II
Appearance: white powder
Specification: Non-hydrolyzed or hydrolyzed
Source: Chicken Cartilage
Other name: Type II Collagen; Non-hydrolyzed Type II Collagen; Hydrolyzed Type II Collagen
What is Collagen Type II?
Type II collagen is a fibrillar protein made up of 3 long alpha chains of amino acids that form a tightly packed network of fibrils and fibers. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.
Type II collagen makes up 50-60% of protein in cartilage and 85-90% of collagen in articular cartilage. It is what gives cartilage its tensile strength and elasticity, thereby enabling it to support the joints, also helps in the binding process with the help of fibronectin and other collagens.
Oral administration of native type II collagen induces oral tolerance to pathological immune responses and useful in arthritis.
What is the benifits, difference between type II collagen and type I collagen?
| Collagen Type | Location | Structure/ Peptide chain | Benifits |
| Type I
Collagen |
Skin & Bone | Three chains
(two alpha 1 & one alpha 2chain) |
Nutrition Support
(Skin, Bone) |
| Type II
collagen |
Cartilage | Three chains
(three alpha 1 chains) |
Nutrition Support (Joint,Cartilage)
Anti-inflammatory Repairing |
What is the benifits, difference between Hydrolyzed and Non-hydrolyzed type II collagen?
| Type II collagen | Molecular weight | Structure/ Peptide chain | Benifits |
| Non-hydrolyzed | NLT 300,000 DA | Orginal Three chains
(Only M.W over 300,000 could keep it) |
Anti-inflammatory Repairing |
| Hydrolyzed | Average 1,000 DA | Orginal Structure are totally Hydrolyzed | Nutrition Support (Joint,Skin,Bone) |
How does Non-hydrolyzed Type II collagen Work?
Under the action of gastric acid and pepsin, Type II collagen is partially hydrolyzed to form sologen, which still maintains the 3-chains structure and the epitope is exposed
APC cells process and present antigen peptides via MHC molecules to activate regulatory T cells (Treg) and Reach inflammatory joints through blood circulation, also lymphatic circulation.
Improve arthritis symptoms and promote normal joint repair.
Recommended Dosage of Hydrolyzed and Non-hydrolyzed type II collagen
Hydrolyzed Type II collagen: 1g/day for skin care; 2g/day for joint care
Non-hydrolyzed type II collagen: 40mg/day