L-Methyfolate Ca(5-MTHF-Ca)

Most active form of folic acid (vitamin B9)


Assay: 99.0% HPLC USP37

Appearance: white powder

CAS NO.: 26560-38-3

Molecular formula:C20H27CaN7O6

Molecular weight: 501.5497

Other name:


5-Methyltetrahydrofolate calcium (racemate);

5-Methyltetrahydrofolate calcium;

What is L-Methyfolate Ca(5-MTHF-Ca)?

L-5-Methyltetrahydrofolate Calcium is a stable and most active form of folic acid(vitamin B9), which can be directly usable by humen body directly, independent of genetic variants of folate dependent enzymes (MTHFR-Methylenetetrahydrofolate reductase). Lifebio provide high quality L-5-Methyltetrahydrofolate Calcium (USP37), which has been registered in US.FDA/NDI, KOSHER,Gras


Why we need folic acid(vitamin B9)?

Sufficient folate levels are critical throughout our entire life. Less than optimal folate intake has been implicated in the etiology of a variety of disorders including anemia, neural tube defects (NTDs), various forms of cardiovascular diseases (CVD), depression, Alzheimer’s disease and osteoporosis.


Why L-Methyfolate Ca(5-MTHF-Ca)?

7 times more bio available than folic acid.

Directly bioavailable, independent of genetic variants of folate dependent enzymes

L-methylfolate is the active form of folate which is directly bioavailable and naturally occurring in foods. In contrast, folic acid must be activated before use by the body. The efficacy of this metabolic process differs from person to person, meaning that folic acid may not be adequately converted into metabolically active folate by some individuals.


Directly involved in lowering blood homocysteine levels

L-methylfolate is directly involved in lowering homocysteine blood levels, which are associated with various forms of cardiovascular diseases.


The only form of folate/folic acid able to cross the blood-brain barrier

The transport into the central nervous system (CNS) is specific for L-methylfolate. Other folate forms need to be transformed into the active form L-methylfolate, before they can be transported into the CNS.


No masking of B12-deficiency

The reaction from L-methylfolate to tetrahydrofolate is B12 dependent. This means that in the case of B12 deficiency, L-methylfolate becomes  “trapped” as it cannot be further biochemically processed.


No risk of accumulating unmodified folate in the body

Given that some individuals cannot sufficiently metabolize folic acid into L-methylfolate due to an enzyme polymorphism, this may lead to unmetabolized folic acid circulating in the human organism. Although folic acid has been consumed for decades, it does not occur in nature and our body is not used to handle it.