Mechanism of action of Lovastatin(monaconlin-K)

Mechanism of action of Lovastatin (monaconlin-K)

Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate.Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. Lovastatin is a prodrug, an inactive lactone in its native form, the gamma-lactone closed ring form in which it is administered, is hydrolysed in vivo to the β-hydroxy acid open ring form; which is the active form.

 

Lovastatin and other statins have been studied for their chemopreventive and chemotherapeutic effects. No such effects were seen in the early studies. More recent investigations revealed some chemopreventive and therapeutic effects, for certain types of cancer, especially in combination of statins with other anticancer drugs. It is likely that these effect are mediated by the properties of statins to reduce proteasome activity, leading to an accumulation of cyclin-dependent kinase inhibitors p21 and p27, and to subsequent G1-phase arrest, as seen in cells of different cancer lines.

 

Natural sources

Lovastatin is a naturally occurring compound found in low concentrations in food such as oyster mushrooms,red yeast rice,and Pu-erh.

 

 

Why Red-Life™-Red Yeast Rice Extract (monacolin-K)?

1. cGMP Manufacturing
2. High purity Monacolin-K 0.4%-5%,
3. High ratio of acid form Monacolin-K, 80% or contract manufacturing
4. Citrinin Free
5. Total plate count NMT 1,000 cfu/g without irradiation
6. Allergen Free/ GMO Free

 

Specifications List of Red-Life™-Red Yeast Rice Extract (monacolin-K)

1. Red Yeast Rice Extract Powder 0.4%-5% monacolin-K
2. Red Yeast Rice Extract Powder Water Soluable
3. Tablet/Capsules Red Yeast Rice Extract (Monaconlin-K) Supplements