Both “folic acid” and “folate(L-Methyfolate Ca/ 5-MTHF-Ca)” are known as Vitamin B9, which is especially important during periods of rapid cell division and growth such as infancy and pregnancy.
With the development of human, folate has been improving from the inactive folic acid to active methylated folate, from the structure of raceme to optical voidness, from the form of amorphous to crystalline.
The commercial folate has been trends to be purer, safer and more stable to satisfy human’s requirement.
Sufficient folate levels are critical throughout our entire life. Less than optimal folate intake has been implicated in the etiology of a variety of disorders including anemia, neural tube defects (NTDs), various forms of cardiovascular diseases (CVD), depression, Alzheimer’s disease and osteoporosis. However, despite the importance of folates, a large part of the population has an insufficient intake of folate from food sources alone.
Folate is the generic term comprising all the folate forms and the synthetic provitamin folic acid. They play a key role in a variety of biochemical reactions and are required, for example, for normal cell division and repair. Natural folates, consisting predominantly of L-methylfolate (such as Metafolin® and Arcofolin™), are found in green leafy vegetables in particular, which also gave this class of substances its name (folium is Latin for leaf).
Unfortunately, it can be challenging to consume the amount of food or beverage necessary to achieve the recommended daily level of folate. For example:
- One liter of orange juice
- One kilogram of vegetables
- ½ kilogram of liver
- Four liters of beer